![]() If Ab is absent, Streptolysin O is free to react with RBC’s resulting in hemolysis.If Ab ( ASO) is present in patient serum, it will bind to SO thus not free to react with indicator RBC’s, the result appears as no hemolysis.After an incubation period, RBC’s are added followed by incubation at 37 c. After diluting patient serum, Streptolysin O is added.Ab ( May be present or absent in patient sample).Ag is streptolysin O =SO (immunogenic).Measurement of ASO can be useful diagnostically to determine if patient has high risk of post streptococcal complications. Levels equal or greater than 200 units per ml are considered significant.ASO antibodies will be raised after infection with streptococci.ASO titer is used for the serological diagnosis of Group A beta- hemolytic streptococcal associated disorders or post complications.Negative reaction: No Wheel and erythemaĢ-In Vitro (Antistreptolysin “O” titration). ![]() Pseudo-positive: when there is only a red colored inflammation and it disappears rapidly.Positive: when the test results in a red necrotic area of 5-10 mm diameter.If the person has immunity, then little or no swelling and redness will occur, indicating a negative result.This swelling disappears after a few days.If a person does not have enough antibodies to fight it off, the skin around the injection will become red and swollen, indicating a positive result.Minimum lethal dose (MLD, also LDmin) is the least amount of drug that can produce death in a given animal species under controlled conditions.Named after its inventor, Béla Schick (1877-1967) Ī small amount (0.1 ml) of diluted (1/50 MLD) diphtheria toxin is injected intradermally into the arm of the person.Schick test - used to determine whether or not a person is susceptible to diphtheria (Corynebacterium diphtheria).
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